50 years ago, Tim Bliss and Terje Lømo worked in the Oslo lab of the late neuroscientist Per Andersen, where they made a momentous discovery: the fact that when a neuron signals to another neuron frequently enough, the second one will later respond more strongly to new signals for hours afterwards. The phenomenon is called long-term potentiation (LTP) and it’s fundamental to how we learn and remember. @KnowableMag talked to Bliss and Lømo about their discovery, and to other neuroscientists about how they’re applying knowledge about LTP to their research about memory disorders, chronic pain and more.

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